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CHEMFORTTM
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Chemfort™ is a membrane to membrane next-generation Closed System Transfer Device based on patented Toxi-Guard® air-cleaning technology. This offers a complete portfolio of products for handling hazardous drugs with confidence.
Chemfort™ includes the benefits of the Tevadaptor product family, our Toxi-Guard® patented air-cleaning technology and upgraded materials and design.
The innovative design of Chemfort™ was created around real-world use and operator feedback, enabling efficient, simple use for pharmacists, nurses and other healthcare professionals. Chemfort™ provides compatability with all know hazardous drugs and has been included in peer-reviewed studies on device safety and efficacy1,2
Handling of Chemfort™ is identical to that of Tevadaptor. These Tevadaptor demonstration videos can be used as reference for Chemfort™ handling.
Chemfort™ is a Closed System Drug Transfer Device (CSTD) designed to help to prevent the escape of hazardous drug vapours into the environment during drug reconstitution and administration. Drug containment in the Chemfort™ Vial Adaptor is accomplished by the TOXI-GUARD® system, which contains a 100% activated carbon drug binding matrix and 0.2 μm hydrophobic and oleophobic membrane. The activated carbon matrix is highly efficient in adsorption of drug vapours. The 0.2 μm membrane is a sterile barrier helping to prevent micro-organisms and particles from entering the system and, due to its hydrophobic and oleophobic properties, helps to prevent aerosols and liquids from being released from the system. Together, they serve as an effective sterile, particulate and toxic drug vapour barrier.
The Toxi-Guard® system ensures that the Chemfort™ air pathway only allows particulate and bacteria-free air to enter the drug vial during drug reconstitution and preparation. It also ensures that the air exiting the drug vial is free of hazardous drugs’ vapour.
Several studies were performed, challenging the efficacy of the Chemfort™ Vial Adaptor to prevent the escape of drug vapours6. A model system was designed to induce drug vapours within the drug vial. Since under normal usage conditions, the drug vapours that are generated are minimal, extreme conditions were employed to significantly increase vapour quantity. Vapours released from the Chemfort™ Vial Adaptor were trapped within a closed test chamber. The trapped drug was collected and then analysed by highly sensitive LC/MS/MS methods.
The Chemfort™ Vial Adaptor was tested with with three commonly used antineoplastic drugs: Cyclophosphamide, 5-Fluorouracil and Doxorubicin. With Cyclophosphamide and 5-Fluorouracil, vapours were consistently detected in control samples in which the TOXI-GUARD® system had been removed from the Chemfort™ Vial Adaptor. In test samples containing an intact TOXI-GUARD® system, no drug vapours were detected. With Doxorubicin no drug vapours were detected in either the positive control or test sample.
These results support the validity of the Chemfort™ Vial Adaptor helping to prevent the release of hazardous drug vapours.
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